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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A 46-year-old man comes into the clinic complaining of facial swelling and difficulty breathing.
Upon examination, it is determined that the patient has facial edema most likely associated with enalapril use. The patient was transferred to the hospital for treatment of the facial edema. It is most appropriate to report this reaction to the:

A) Vaccine Adverse Event Reporting System.
B) MEDMARX database.
C) FDA.
D) Drug manufacturer.

2. In a clinical trial, when would "intention to treat" analysis be most appropriate?

A) High drop-out rate
B) Phase || trial
C) Small sample size
D) Crossover design

3. A pharmacotherapy specialist is interpreting a published paper describing a randomized controlled, double-bling study that was conducted to evaluate the effects of antihistamines on the failure rate of treatment of otitis media in children. In the study, 250 children received antihistamines and 264 did not. All children received appropriate antibiotic therapy. Treatment failures occurred in four (1.6%) of the children who received antihistamines and in 13 (4.9%) of those who did not. The difference is statistically significant (p<0.05, chi-square). Which of the following statements about these result is appropriate?

A) Chi-square is not the appropriate statistical test.
B) Knowledge of the rate and severity of adverse event in the study is needed to allow a therapeutic decision.
C) The sample size is inadequate to allow clinical conclusions.
D) Antihistamines should be administered to all children with otitis media who meet study entry criteria.

4. A study is conducted comparing two antibiotics for the treatment of UTIs. The results after 7 days of therapy demonstrated that Drug A was superior to Drug B in eradicating bacteria from the urine and eliminating signs and symptoms of infections. The investigators concluded that Drug A was significantly superior to Drug B (p<0.05). In subsequent studies, however, the two drugs were equivalent in efficacy.
Which one of the following types of error apparently occurred in the first study?

A) Regression to the mean
B) Beta error
C) Type |
D) Type ||

5. A Woman with a history of poison-ivy allergic contact dermatitis presents with widespread well demarcated patches of erythema and vesicles that are oozing and Weeping. Her eyes are nearly closed, due to swelling. Which of the following drugs is most appropriate for this patient?

A) Diphenhydramine
B) Oral prednisone Oral
C) Epinephrine subcutaneous
D) Topical triamcinolone

Solutions: